PIRFENIDONE INHIBITS HYPOXIC PULMONARY HYPERTENSION THROUGH THE NADPH/ROS/P38 PATHWAY IN ADVENTITIAL FIBROBLASTS IN THE PULMONARY ARTERY

Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery

Hypoxic pulmonary hypertension (HPH) is a devastating disease characterized by progressive vasoconstriction bekindtopets.com and vascular remodeling.Pirfenidone (PFD) inhibits the progression of HPH, though the molecular mechanisms remain unknown.This study is aimed at determining the role and mechanism of PFD in HPH in human pulmonary artery adven

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Pattern and Outcome of Pediatric Cardiac Surgery in University of Nigeria Teaching Hospital, Enugu: A Setting of West African Sub-region

Background: Paediatric cardiac surgery is highly challenging, especially in resource-limited economy like ours.The burden of heart diseases in children is huge and increasing thus, the need to audit the bold step resumed by our center in the last 5 years.OBJECTIVE: To determine the pattern and outcome of Paediatric open heart surgeries done in a te

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