Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery
Hypoxic pulmonary hypertension (HPH) is a devastating disease characterized by progressive vasoconstriction bekindtopets.com and vascular remodeling.Pirfenidone (PFD) inhibits the progression of HPH, though the molecular mechanisms remain unknown.This study is aimed at determining the role and mechanism of PFD in HPH in human pulmonary artery adven